The race for the title is set to go down the wire, pitting Manchester City and Liverpool who have since had the top two slots sorted.
Man City's victory over Cardiff City saw them move to the summit of the standings with 80 points, a point ahead of Jurgen Klopp's men.
Only three points are separating third-placed Tottenham Hotspurs and sixth-placed Manchester United, leaving the top four race open.
Spurs defeated Crystal Palace 2-0 at their new stadium to leapfrog Arsenal to go third with 64 points.
However, the Gunners still have a match to play and could move into third once again should they earn a win or a goal-scoring draw against Everton at Goodison Park.
Elsewhere, Chelsea's 3-0 convincing win over Brighton at Stamford Bridge moved them to fifth on the log, with Man United effectively dropping to sixth having lost their league match to Wolves on Tuesday, April 2.
As such, four teams remain strongly in contention for the two places left for Champions League slots in the EPL.
Meanwhile, Fulham and Huddersfield Town have since confirmed their relegation to Championship with six matches left to end the season.
Cardiff City, Burnley, Southampton and Brighton are the other teams battling for survival.